For the CM4, I’d either recommend using Rex’s Debian Bookworm distro (if you’re used to Raspberry Pi OS) or PostmarketOS (if you want a distro from a community that provides long term support). PostmarketOS is based on Alpine linux, which is quite different from Debian.
I currently use Moonlight to remote into my computer, but it’s made for games and is probably not as bandwidth or power efficient as Remmina.
If you want to waste a ton of time, I did get Balatro working: Run Balatro (and other Love2D games) natively on the uConsole